CD8A and systemic lupus erythematosus: CD8+ Tn MMP-Low (AUC = 0.832, P < 0.001; Figure 4A), CD8+Tem MMP-Low (AUC = 0.835, P < 0.001, Figure 4B), CD8+ Tcm MMP-Low (AUC = 0.81, P < 0.001; Figure 4C), and SCMM-CD8+ Tn (AUC = 0.815, P < 0.001; Figure 4D) cells showed a moderate diagnostic value for SLE, as indicated by their AUC values exceeding 0.8 (Table 3).