In addition, CD3+ T cell MMP-Low (r = 0.333, P = 0.016; Supplementary Figure S3) and CD3+CD8+ T cell MMP-Low (r = 0.328, P = 0.018; Supplementary Figure S3) were positively associated with C3 in patients with SLE, while SCMM-CD3+ T cells (r = 0.-309, P = 0.026; Supplementary Figure S3), SCMM-CD3+CD4+ T cells (r = −0.339, P = 0.014; Supplementary Figure S3), and SCMM-CD3+CD8+ T cells (r = −0.324, P = 0.019; Supplementary Figure S3) was negatively associated with C3. The gene discussed is CD8A; the disease is systemic lupus erythematosus.