In CD8+T cell subsets, the percentages of CD8+Tn MMP-Low (P < 0.001), CD8+ Tef MMP-Low (P < 0.001), CD8+Tem MMP-Low (P < 0.001), and CD8+Tcm MMP-Low (P < 0.001) were significantly decreased in patients with SLE (Figure 2A). The gene discussed is CD8A; the disease is systemic lupus erythematosus.