Intriguingly, CTCF interacting protein nucleoporin 153 [61] and condensin complex subunits SMC4 and SMC2 [62] served as negative regulators of CTCF were all enriched in the MEG3 lncRNP, further investigation on the interactions between MEG3 and these factors will help to address the detailed mechanism of MEG3 in cancer progression by regulating downstream target genes. The gene discussed is MEG3; the disease is cancer.