For apoptosis research in PRAD, Raffo et al. demonstrated that overexpression of antiapoptotic Bcl-2 protects PRAD cells from apoptosis [14] and that overexpressed antiapoptotic proteins Bcl-X and Mcl-1 in high-grade and metastatic PRAD promote cancer resistance to apoptosis [15]. This evidence concerns the gene BCL2 and prostate adenocarcinoma.