EPHB1 and prostate adenocarcinoma: We observed a trend of upregulation of multiple genes (especially EPHB1 and KIF13A) in two PRAD cell lines (22RV1 and PC-3) (p < 0.05, Figure 2), and EPHB1, with the highest mutation frequency, was also significantly upregulated in C4-2, DU145, and C4-2B tumor cells (p < 0.05, Figures 2, 2, and 2).