Studies have found that EPHB1 is upregulated by activating PI3K/Akt/NF-κB signaling in a chronic ocular hypertension (COH) model used to analyze the apoptosis of retinal ganglion cells (RGCs) [19] and that EPHB1 is also involved in the regulation of apoptosis during PRAD progression [20]. This evidence concerns the gene EPHB1 and Cohen syndrome.