IFNG and colitis: Additionally, in the DSS‐induced acute colitis model, OLE suppresses Th17 responses by decreasing the CD4+ Rorγt+ IL‐17+ IFN‐γ + T‐cell subset in the submucosal layer of the intestines, along with lower expression levels of IL‐17A and IFN‐γ (Giner et al. 2016).