PLEKHO2 and neoplasm: When the tumor culture media of A172, TJ905 and U87MG cells were co-cultured with THP1 after PMA treatment, it was observed that the expression of C3 and SLA genes was considerably elevated, while the expression of AP1B1, CD53, GAL3ST4, PLEKHO2, PLXDC2, SLC37A2, and TREM2 genes showed significant reduction (Figure 8B).