Another study found that topoisomerase inhibitor SN-38 conjugated nanoparticles packed with anti-CD133 antibodies bound efficiently to overexpressing CD133 cells (CD133Ab-NP-SN-38) in HCT116 colon cancer cells (381), showing cytotoxicity and inhibiting colony formation when compared with non-targeted nanoparticles (NP-SN-38) (381). The gene discussed is PROM1; the disease is malignant colon neoplasm.