Accordingly, many tumor-associated genes (oncogenes, drug-resistant genes, tumor suppressor genes, immune evasion genes, and metabolic reprogramming genes) are targeted through CRISPR-Cas9, for instance, KRAS, p53, EGFR, PTEN, Nestin, BRAF, HASPIN FGFR, FAK, BRCA gene, PIK3CA, VEGFR, HER2, LDHA, NADK, ALK, NOTCH1, PD-L1, ABCB1, TERT, and LGALS2 (190, 242, 245, 247–254). The gene discussed is PIK3CA; the disease is neoplasm.