The transient receptor potential vanilloid family type 2 (TRPV2)-PEGylated carbon nanohorn (PCNH) was found to reduce cancer stemness in the presence of NIR irradiation (517) by activating Ca2+ influx, hence altering intracellular Ca2+ overload, which has been shown to cause apoptosis with TRPV2 overexpression. This evidence concerns the gene TRPV2 and cancer.