AKT1 and hepatocellular carcinoma: It was also observed that exosome p120ctn did not impact PI3A/Akt or MEK/ERK pathways; however, STAT3 phosphorylation was vividly decreased in hepatocellular carcinoma cells, suggesting that the exosome p120ctn disables STAT3 to impede the hepatocellular carcinoma cell proliferation, metastasis, and expansion of the respective CSCs (454).