The development of poly(styrene-b-ethylene oxide) (PS-b-PEO) and poly(lactic-co-glycolic) acid (PLGA) by double emulsions loaded with covalently bound temozolomide (TMZ) and/or RG7388 (idasanutlin) to CD133 aptamer, resulting in the possibility of targeting glioblastoma CSCs in combination with simultaneous diagnostic imaging, has been demonstrated (413). Here, PROM1 is linked to glioblastoma.