Significant factors identified included liver cirrhosis (OR = 4.4, P = 0.001), total bilirubin > 42 μmol/L (OR = 2.1, P = 0.036), Alanine aminotransferase (ALT) > 42 IU/L (OR = 2.2, P = 0.032), Alanine aminotransferase (AST) > 42 IU/L (OR = 2.8, P = 0.018), Alanine aminotransferase (ALP) > 188 U/L (OR = 4.9, P = 0.009), PTBD (OR = 1.9, P = 0.006), and Bismuth–Corlette type III–IV classification (OR = 2.4, P = 0.002). The gene discussed is GPT; the disease is cirrhosis of liver.