Resveratrol, hesperetin, quercetin, epigallocatechin-3-gallate, and cantharidin are all examples of polyphenols that can inhibit GLUT1 mRNA and protein levels in cancer cells, leading to reduced glucose uptake and inhibition of cancer cell metastasis.138, 139, 140, 141 Current research on breast tumors suggests that the up-regulation of GLUT4 expression to induce aerobic glycolysis contributes to drug resistance in targeted cancer therapy. This evidence concerns the gene SLC2A4 and cancer.