A recent study that combined several preclinical models for hepatocellular carcinoma (tumor cell lines, cell line-derived xenograft, PDX, and patient-derived organoid) confirmed that diclofenac exerted anti-hepatocellular carcinoma effects by inhibiting NMT1 (N-myristoyl transferase 1)-mediated myristoylation of the VILIP3 protein.150. The gene discussed is NMT1; the disease is hepatocellular carcinoma.