They identified dual antipruritic mechanisms through cutaneous BO application: TRPA1/TRPM8-dependent suppression of chloroquine-induced nonhistaminergic itch via calcium flux modulation in transfected HEK293 cells and TRPA1/TRPM8-independent inhibition of compound 48/80-mediated histaminergic itch. This evidence concerns the gene TRPA1 and bronchiolitis obliterans syndrome.