Similarly, PERK inhibition markedly suppresses tumor growth and angiogenesis in an orthotopic squamous cell carcinoma model by reducing the expression of FGF2, VEGF, and IL‐6, while increasing the levels of antiangiogenic cytokines/chemokines such as thrombospondin 1 (THBS1), CXCL14, and CXCL10 [84]. This evidence concerns the gene EIF2AK3 and neoplasm.