Researches by relevant scholars have revealed that CBFA2T3-GLIS2 exerts downstream effects through fusion binding and upregulated transcription factor gene network, resulting in dysregulation of developmental pathway signals including NOTCH, Hedgehog, TGFβ and WNT, thereby mediating the occurrence and progression of AMKL. Here, CBFA2T3 is linked to acute megakaryoblastic leukemia.