Using mass spectrometry (SIM MS), they found LRG levels were >100-fold higher in appendicitis patients vs. controls (AUC = 0.98, 95% CI 0.96–1.0), outperforming standard markers like CRP (AUC = 0.76) and neutrophil count (AUC = 0.73). This evidence concerns the gene CRP and appendicitis.