Progressive supranuclear palsy (PSP), a 4R-tauopathy characterized by subcortical tau inclusions in neurons, astrocytes, and oligodendroglia, is associated with various clinical phenotypes (Kovacs et al., 2020; Höglinger et al., 2017a; Shi et al., 2021; Stamelou et al., 2021). The gene discussed is MAPT; the disease is Classical progressive supranuclear palsy.