CRP and infection: 11.3. We do not recommend the use of antimicrobial therapy to treat infected pancreatic necrosis on the basis of clinical symptoms and CRP measurements alone. Diagnosis of the infection of pancreatic necrosis should be based on imaging studies (eg, contrast-enhanced abdominal CT scans). However, we recommend that procalcitonin levels be monitored to optimize the use of antimicrobial drugs.