Also, a prospective cohort study published in 2022 confirmed the use‐ fulness of CRP and procalcitonin level determination in the diagnosis of this complication.(Wiese et al., 2022),(Alberti et al., 2022) On the other hand, a prospective RCT (PROCAP) published in 2022 revealed that an antibiotic therapy algorithm based on procalcitonin levels in AP patients facilitates significant reduction in antibiotic use without an increase in the rate of infections during the course of the disease.(Siriwardena et al., 2022). This evidence concerns the gene CRP and alkaline phosphatase measurement.