INS and hypertriglyceridemia: 16.6. For significant hypertriglyceridemia, we suggest insulin infusion, especially in diabetic patients, and for persistently high TG values in patients with severe (>11.3 mmol/l) or very severe (>22.4 mmol/l) hypertriglyceridemia, we recommend considering therapeutic plasma exchange, especially if there is no response to conservative treatment (fibrates, heparin, insulin). (GRADE 2C)