Lyophlised Apilarnil contains 21.1–24.2% lipids and 52.62% CLA (% of total fatty acids). Previously, studies have reported that insulinresistance in obese/diabetic mice is promoted by CLA nutrition, whichinversely regulates leptin and adiponectin, known to either improveor worsen insulin sensitivity. Also,palmitic acid can contribute to aberrant insulin regulation of glucosemetabolism in type 2 diabetes. Therefore,high doses of Apilarnil might have failed to improve dyslipidemicconditions in type 2 diabetic rats. The gene discussed is LEP; the disease is type 2 diabetes mellitus.