Inhibition of the IRS-1/PI3K/Akt pathway disruptsthe regulation of metabolic functions such as glucose transport, adipogenesis,glycogen synthesis, and protein synthesis., Therefore, type 2 diabetes disrupts glycogen synthesis by affectingthe IRS-1/PI3K/Akt pathway in the liver, and causes insulin resistanceby affecting the IRS-1/PI3K/Akt/GLUT4 pathway in peripheral tissues.Insulin resistance leads to hyperglycemia and reactive oxygen species,which cause an increase in the severity of oxidative stress. The gene discussed is AKT1; the disease is Insulin resistance.