In addition, levels of antioxidant enzymes such asCAT and SOD may decrease due to decreased Nrf2 activity., In this regard, similar to previous studies, in our study, it wasobserved that the levels of NF-κB, and TNF-α, proteins increased in the liver tissues of animals due to inflammationinduced by type 2 diabetes. This evidence concerns the gene SOD1 and type 2 diabetes mellitus.