IRS1 and type 2 diabetes mellitus: In type 2 diabetes, the levels of PI3K p85and p-Akt proteins are decreased in the liver, muscle, and visceralfat tissue., In this study, after inducingtype 2 diabetes using HFD and STZ, there was a decrease in the levelsof IRS-1, PI3K, and GLUT4 proteins in the liver and muscle tissue,as well as a suppression in the levels of phosphorylation of IRS-1and Akt.