IRS1 and type 2 diabetes mellitus: Nrf2 (p < 0.0001), total IRS-1 (p < 0.01), p-IRS-1(p < 0.0001), p-Akt (p < 0.0001)and PI3K p85 (p < 0.0001) proteins were significantlysuppressed in the livers of type 2 diabetes-induced animals (Figure ).