The rats were divided into 5 groups as Control, Diabetes, Diabetes+ Api1 (125 mg/kg/day lyophilized Apilarnil), Diabetes + Api2 (250mg/kg/day lyophilized Apilarnil) and Diabetes + Api3 (500 mg/kg/daylyophilized Apilarnil). The gene discussed is BIRC3; the disease is diabetes mellitus.