It is built up with both nucleus-and mitochondrion-encoded subunits, andthe mitochondrial origin COXIII is a common biomarker for nephropathy.−,  We showed that the induction of COXIII mRNA expression in the IS-stimulatingcells was blocked in the presence of klotho (∼40% inhibition).However, inhibition of AKT/Nrf2 signaling abrogated the effect ofklotho on COXIII suppression (∼11% and ∼6% inhibition)(Figure A). Here, MT-CO3 is linked to kidney disorder.