INS and Hypoglycemia: Although our findings indicated no significant differences between URAI and standard insulin in terms of TIR (both 70-180 mg/dL and 70-140 mg/dL) or TAR (both >180 mg/dL and >250 mg/dL), URAI demonstrated a clinically meaningful advantage by significantly reducing the time spent in mild hypoglycemia (<70 mg/dL), with a mean difference of 0.33%.