In this study, further investigation demonstrated its superior effects in promoting insulin sensitivity, preventing hypercholesterolemia, hypertriglyceridemia, fat accumulation in the liver, and body weight gain in a high-fat diet (HFD) animal model compared to the HFD-PBS-treated group, as well as the commercial probiotic Bifidobacterium animalis subsp. The gene discussed is INS; the disease is familial hypercholesterolemia.