NOS2 and neoplasm: The top 15 upregulated genes (Figure 7D) included Ifng and Nos2, IFN-inducible chemokine Cxcl9, IFNγ-inducible GTPase Gm4841, Tlr12, serine protease inhibitor genes Serpina3i and Serpina3g. Other upregulated genes comprised Ubd, Cnn3, Upp1, Clec9a, Slc6a19, Ly6a and Ptgs2, responsible for producing inflammatory prostaglandins and its upregulation is linked to increased cell adhesion, phenotypic changes, resistance to apoptosis and enhanced tumour angiogenesis [49].