Magnesium channel, TRPM6 located within the DCT are less active due to absorption of Ca2+ within the proximal tubule leading to hypocalciuria, and hypomagnesemia present in GS.2 Reabsorption of Ca2+, by passive reabsorption within the proximal tubule and decreased Mg2+-channel TRPM6, located within the DCT. Here, TRPM6 is linked to familial primary hypomagnesemia.