FAM151B and retinal degeneration: No research has been conducted on the impact of FAM151A in CRC; however, Fam151B homozygous knockout mice develop retinal degeneration, with signs of retinal stress and rapid loss of photoreceptor cells in the eye, while FAM151A homozygous mutant mice have no discernable phenotype, suggesting that Fam151b and FAM151A may be functionally different (Findlay et al., 2020).