It has been previously reported that the implantation of poly (lactide-co-glycolide) scaffolds into the epididymal fat of mice on a high-fat diet protected against hyperinsulinemia and ectopic fat accumulation in the liver and skeletal muscles; and the positive effects correlated with increased CPT1A enzyme expression in multinucleated giant cells surrounding the implant, which catabolizes fatty acids (Hendley et al., 2020). The gene discussed is CPT1A; the disease is Hyperinsulinemia.