Specifically, compared to the control group, the AD group exhibited up-regulation in pathways such as notch signaling, IL6 JAK STAT3 signaling, interferon alpha and gamma responses, epithelial mesenchymal transition, TNFA signaling via NFKB, inflammatory response, hypoxia, apical surface, and P53 pathway. The gene discussed is TNF; the disease is Alzheimer disease.