In conclusion, the classical EAMG model in rodents studied herein is considered relevant to investigate novel therapeutic modalities for MG (22, 69) and indeed, the mouse EAMG model has been previously used to evaluate the efficacy of several clinical candidates, including TNFR-Fc (70), teriflunomide (71), and anti-IL-23 (72). The gene discussed is TNFRSF1A; the disease is myasthenia gravis.