IGSF11 and breast neoplasm: Similarly, in METABRIC cohort, NK cells maintained this pattern of upregulated inhibitory checkpoints and exhibited upregulation of additional molecules, particularly TIGIT, BTLA, and IGSF11, with VSIG8 consistently downregulated, reinforcing the hypothesis of Siglec-7 mediated suppression of NK cell activity within breast tumor microenvironment.