Consistent with our results, a previous study reported increased mutation frequencies of FAM135B and downregulation of genes such as CD8A, GBP5, KIAA0040, and SAMHD1 in the iC3 subtype, which is associated with the most aggressive SKCM cases, highlighting the critical role these genes play in tumor progression and immune response (64). The gene discussed is CD8A; the disease is neoplasm.