Overexpression of B cell-activating factor (BAFF) system molecules has been detected in patients with various types of autoimmune diseases, such as systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), systemic sclerosis (SSc), bullous pemphigoid (BP), pemphigus vulgaris (PV), and alopecia areata (AA) (Figure 3). Here, TNFSF13B is linked to autoimmune disease.