KMT2A and leukemia: Murine ZFP64 isoform 1 shares sequence similarities with human ZFP64 isoform A, but minor differences with human ZFP64 isoform B and C.27The human ZFP64 isoform A is known to maintain the expression of KMT2A/MLL encoding a histone-lysine N-methyltransferase and is involved in leukemia growth via a C-terminal transactivation domain.28