S100B and Encephalopathy: In contrast, no correlation with encephalopathy type was reported for NSE levels.26In the same study, only increased S100β levels were associated with ICU mortality, while GCS scores or NSE levels were not helpful for outcome prediction.26Wu et al measured the levels of S100β in septic patients on days 1 and 3 after ICU admission and found higher S100β in both measurements in septic patients with SAE than in non-SAE.