In SAE patients, the NSE levels increased in the CSF, while the plasma values were similar across the groups.28Interestingly, mean CSF NT-pro-CNP levels were higher in patients with septic brain lesions on MRI compared to those without brain lesions.28The relationship between inflammation and the release of NT-pro-CNP in CSF is supported by the correlation between elevated levels of CSF NT-pro-CNP and IL-6, and plasma procalcitonin levels.28NT-pro-CNP is considered a promising biomarker for SAE because its levels peak in the early stages of sepsis. This evidence concerns the gene ENO2 and Sepsis.