In their study, Zujalovic et al demonstrated a statistically significant change in AChE-activity for at least 5 consecutive days compared to baseline in septic patients with SAE, while no significant changes in AChE-activity were reported in nonseptic patients, even in those with delirium.32According to their results, the longitudinal measurement of AChE activity could be helpful in the diagnosis of SAE. Here, ACHE is linked to delirium.