In their study comparing sepsis patients with SAE and matched healthy controls, Orhun et al reported significantly increased IL-8, IL-6, and IL-10 and significantly decreased TNF-α and IL-12 in patients with SAE as compared to healthy controls.13The levels of complement breakdown and activation products studied, such as C4d, were also increased, while C5a and iC3b showed decreased levels in patients with SAE compared to healthy individuals.13 Here, TNF is linked to Sepsis.