Although the precise mechanism by which Aβ triggers neuroinflammatory and oxidative stress processes is intricate, there exists compelling evidence that the silent mating‐type information regulation 2 homolog 6 (SIRT6)/nod‐like receptor thermal protein domain‐associated protein 3 (NLRP3) signaling pathways are involved in the pathogenesis of AD.12, 13. The gene discussed is SIRT6; the disease is Alzheimer disease.