AKT1 and acute kidney injury: Glutamine reduced oxidative stress in gentamicin-induced AKI in rats (Zhan et al., 2022), targeted microRNA/Notch and microRNA/phosphoinositide-3-kinase/protein kinase B signaling pathways in IR rats (Li S. et al., 2022), reduced organic cation transporter2 expression, and reduced the absorption of cisplatin HK-2 cells (Kim et al., 2015), among other mechanisms.