Inhibiting glycolytic enzyme HK promotes autophagy, suppresses apoptosis and improves kidney function by enhancing SIRT3/AMPK pathway in LPS-induced AKI (Tan et al., 2021)Inhibiting glycolytic enzyme PKM2 reduces kidney fibrosis, tubular apoptosis, and macrophage infiltration in UUO-induced injury (Wei et al., 2019). Here, SIRT3 is linked to acute kidney injury.