The gene expression of kidney BCAAs catabolism-related genes, such as Bckdha, Bckdhb, Acadm, Mut, Ivd, Hibch, Mccc1, and Mccc2, significantly decreased in Cisplatin, aristolochic acid I-induced and UUO-induced AKI (Piret et al., 2021). Here, MCCC1 is linked to acute kidney injury.