Inhibition of catabolic enzyme AOC1 reduces cortical tubules with casts and downregulates injury markers in IR-induced AKI (Sieckmann et al., 2023)Inhibition of catabolic enzyme SAT reduces inflammatory reactions, reduces neutrophil infiltration, TNF-α, MCP-1, and IL-6 expression in IR-induced AKI (Zahedi et al., 2014)Inhibition of catabolic enzyme SAT or SMOX reduces endoplasmic reticulum stress response in cisplatin-induced AKI (Zahedi et al., 2017)Overexpression of catabolic enzyme SAT increases oxidative stress in IR-induced AKI (Wang et al., 2004). The gene discussed is IL6; the disease is acute kidney injury.