Produces ROS and worsening of kidney injury in IR-induced AKI (Oh et al., 2023)Promotes apoptosis by activating SUCNR1/ERK in HK-2 cells, induces apparent renal injury in succinate-treated mice (Pu et al., 2023)Activates the RAS system by activating SUCNR1/NO/PGE2 in JGA (Deen and Robben, 2011)Polarizes macrophages by activating the SUCNR1/PI3κ/HIF-1α axis (Wu et al., 2020)Blocks mitochondrial FAO and increases peroxisome FAO by increasing succinylation in cisplatin-induced AKI (Chiba et al., 2019). The gene discussed is HIF1A; the disease is acute kidney injury.