With regard to the kidney, proteomics revealed a significant decrease in the protein levels of BCAA catabolic enzymes, including BCKD E1 subunit alpha (BCKDHA), BCKD E1 subunit beta (BCKHB), mitochondrial medium-chain specific acyl-CoA dehydrogenase (ACADM), isovaleryl-CoA dehydrogenase (IVD), 3-hydroxyisobutyryl-CoA hydrolase (HIBCH), and methylcrotonoyl-CoA carboxylase (MCCC1, MCCC2), in LPS-induced AKI in mice kidney (Xu et al., 2023). Here, MCCC2 is linked to acute kidney injury.