Inhibiting enzyme PDK4 mitigates oxidative stress, elevates mitochondrial membrane potential and ATP production, reduces mitochondrial fragmentation in IR-induced kidney injury (Oh et al., 2023)Inhibiting enzyme PDK reduces kidney fibrosis, tubular apoptosis, and macrophage infiltration in UUO-induced injury (Wei et al., 2019). This evidence concerns the gene PDK4 and kidney injury.