Hu et al. confirmed that enhanced O-GlcNAc signaling transduction reduced oxidative stress and cell apoptosis through inhibiting phosphorylation of protein kinase B. Inhibition of this process using alloxan, an OGT inhibitor, worsened kidney function in contrast-induced-AKI (Hu et al., 2017). The gene discussed is AKT1; the disease is acute kidney injury.