SLPI and Increased total eosinophil count: After injection with pCMV SLPI (wild-type SLPI), Alternaria-treated SLPI KO mice displayed airway inflammation evaluated by histological examination, total BAL cell count, the ratio of eosinophilia in BAL, and levels of Th2 cytokines including IL-5 and IL-13 in BAL fluid, which were significantly decreased compared to those injected with pCMV CTRL (Figures 5A-5D).