In contrast to mice treated with the control IgG antibody to SLPI KO mice, SLPI KO mice treated with anti-IL-33 neutralizing antibody showed reduced airway inflammation and fewer numbers of BAL total cells, ratio of eosinophilia, and Th2 cytokines (e.g., IL-5 and IL-13) in BAL fluid (Figures 4A-4D). The gene discussed is IL33; the disease is Increased total eosinophil count.