As shown in Figures 2A-2D, a similar trend was observed in two mouse models of downregulated SLPI gene. WT mice injected with pshSLPI (SLPI-targeting shRNA) also showed enhanced airway inflammation from Alternaria extract exposure in the histological examination, total BAL cell count, ratio of eosinophilia in BAL, and levels of Th2-type cytokines (e.g., IL-5 and IL-13) in BAL fluid compared to WT mice injected with control shRNA (pshCTRL). Here, IL5 is linked to Increased total eosinophil count.