Cobalamin (Vitamin B12) deficiency is common, often linked to the use of medications for obesity-related comorbidities, such as metformin, proton pump inhibitors, angiotensin-converting enzyme inhibitors, and colchicine, with small intestinal bacterial overgrowth further exacerbating the condition [7]. The gene discussed is ACE; the disease is obesity due to melanocortin 4 receptor deficiency.