MWS-DAS: Muckle-Wells Syndrome-Disease Activity Score; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; SAA: serum amyloid A; S100A12: S100 calcium-binding protein A12; GI: gastrointestinal; NLRP3: NACHT, LRR, and PYD domains-containing protein 3 (also known as cryopyrin). Here, NLRP3 is linked to Muckle-Wells syndrome.