Abbreviations: HbA1c, hemoglobin A1c; T2DM, type 2 diabetes mellitus; CAD, coronary artery disease; GERD, gastroesophageal reflux disease; SGLT2, sodium-glucose cotransporter-2; DKA, diabetic ketoacidosis; ICU, intensive care unit. The gene discussed is SLC5A2; the disease is diabetes mellitus.