A 46-year-old female patient, known to have squamous cell carcinoma of the cervix, metastatic to the lungs, bone, and liver, negative for human epidermal growth factor receptor 2 (HER2), negative for microsatellite instability (MSI), and negative for programmed death-ligand 1 receptor (PD-L1), treated by hysterectomy and chemotherapy (cisplatin 40 mg/m2 weekly for seven cycles) with radiotherapy concomitantly, presented to the Emergency Department for multiple episodes of bloody vomiting, compatible with hematemesis. Here, ERBB2 is linked to cervical squamous cell carcinoma.