PTH and chronic kidney disease: Treatment involves a multidisciplinary approach with four main goals: adequate pain control with opioids; correction of bone-mineral metabolism abnormalities in CKD, addressing calcium, phosphorus, PTH, and calcium-phosphorus product levels; optimization of wound care with judicious use of surgical debridement, dressings, and hyperbaric oxygen therapy; and halting the progression and reversing vascular calcification with sodium thiosulfate (STS) or vitamin K supplementation [2,8].