DEG network analysis revealed 1074 nodes and 13,148 edges, while hub gene analysis identified DLGAP5, KIF23, KIF11, CCNB1, CDK1, BRCA1, CCNA2, SHCBP1, KIAA0101, FAM83D, and SPC25 as critical HCC-associated genes. This evidence concerns the gene SPC25 and hepatocellular carcinoma.