Compared with the IL-1β group, the level of p70 S6K1 decreased while the levels of p-S6K1 and p-S6 increased in the E2 group, suggesting that E2 can inhibit IL-1β-induced NPC apoptosis by activating the p70 S6K1 signaling pathway (Figures 4A–D). Here, RPS6KB1 is linked to nasopharyngeal carcinoma.