The first article was published in 2013 by Feng et al. (17), which demonstrated that electroacupuncture at Baihui (DU20) and Shenting (DU24) acupoints ameliorates cognitive impairment in cerebral ischemia–reperfusion injured rats by inhibiting NF-κB-mediated neuronal apoptosis through suppression of pro-apoptotic Bax and Fas expression, thereby reducing infarct volume and improving neurobehavioral outcomes. This evidence concerns the gene NFKB1 and Cognitive impairment.