In this study, we demonstrate that treatment with BYHWD significantly reduced the levels of pro‐inflammatory cytokines in the hippocampus of 3×Tg mice, suggesting that BYHWD may attenuate neuroinflammation and slow the neurodegenerative processes in AD by inhibiting the C/EBPβ‐AEP axis. This evidence concerns the gene CEBPB and Alzheimer disease.