To examine whether TMEM65 promotes TNBC progression via regulating SERPINB3, we stably reintroduced SERPINB3 into TMEM65‐depleted SUM159PT and Hs578T cells (Figure S10, Supporting Information), and then we carried out in vitro experiments and xenograft tumor growth assays in vivo. Here, SERPINB3 is linked to neoplasm.