Previous studies have shown that SERPINB3 is a multifaceted oncogene involved in regulating cancer stemness,[43, 44] epithelial‐mesenchymal transformation,[26] tumor immunity,[45] and cancer‐related inflammation,[46] and is closely related to the progression of multiple types of human cancer.[22, 23] Thus, we chose the top‐ranked downregulated protein SERPINB3 following knockdown of TMEM65 for further validation. Here, SERPINB3 is linked to cancer.