As expected, ectopic expression of TMEM65 increased (Figure7A), whereas knockdown of TMEM65 decreased (Figure 7B), the expression levels of SERPINB3 as well as the well‐documented cancer stem cell (CSC) markers including ALDH1A1 (aldehyde dehydrogenase 1 family member A1), CD44, and Nanog.[51] Moreover, knockdown of SERPINB3 in TMEM65‐overexpressing cells attenuated TMEM65‐induced upregulation of ALDH1A1, CD44, and Nanog (Figure 7C). Here, CD44 is linked to cancer.