FOXM1 and colonic neoplasm: During HF, the heart faces an energy deficit, which is primarily due to decreased mitochondrial oxidative capacity.[35] In colon cancer, it has been shown that FOXM1 inhibition has the potential to result in mitochondrial dysfunction and enhance sensitization to anticancer drugs.[28] Researchers have also found evidence supporting a critical role of FOXM1 in the regulation of aerobic glycolysis.[36, 37] In addition, Black et al.