MPO and colitis: NLRP3 inflammasome activation, resulting from plasma membrane rupture, promotes macrophage lytic death – a process that may facilitate bacterial dissemination or crystal propagation.[27] In vivo, hepatic tissues from indirubin‐treated colitis mice exhibited extracellular deposition of citrullinated histone H3 (H3Cit) and myeloperoxidase (MPO), markers of macrophage extracellular traps (METs) (Figure 6F).