NLRP3 inflammasome activation, resulting from plasma membrane rupture, promotes macrophage lytic death – a process that may facilitate bacterial dissemination or crystal propagation.[27] In vivo, hepatic tissues from indirubin‐treated colitis mice exhibited extracellular deposition of citrullinated histone H3 (H3Cit) and myeloperoxidase (MPO), markers of macrophage extracellular traps (METs) (Figure 6F). This evidence concerns the gene NLRP3 and colitis.