CD8+ T cells are critical mediators of immune responses, playing a pivotal role in the defense against infections, the surveillance of tumorigenesis, and the regulation of autoimmune diseases.[1, 2] These cytotoxic lymphocytes exert their functions through the recognition and elimination of infected or malignant cells, primarily by inducing apoptosis via the release of cytotoxic molecules such as perforin and granzymes[3] The effectiveness of CD8+ T cells in these processes is largely dependent on their metabolic flexibility and mitochondrial function. This evidence concerns the gene CD8A and autoimmune disease.