This fusion is crucial for the enhanced antitumor activity of CD8+ T cells in murine and human models, underscoring the role of mitochondrial dynamics in improving CD8+ T cell function during cancer immunotherapy.[13] Additionally, SENP1 promotes CD8+ T cell memory development by deSUMOylating SIRT3, enhancing its deacetylase activity, which drives OXPHOS and mitochondrial fusion. This evidence concerns the gene CD8A and cancer.