This temperature‐induced boost in mitochondrial translation improves the therapeutic efficacy of T cells in a myeloid leukemia model, suggesting that febrile temperature exposure could be harnessed to enhance T cell‐based immunotherapies.[106] In addition, combinatorial anti‐PD‐L1/cryoablation therapy enhances mitochondrial function in PD‐1+CD8+ T cells, leading to improved IFN‐γ production and antitumor activity in a lung cancer model. This evidence concerns the gene CD8A and lung cancer.