Using the “OptoMito‐On” optogenetic tool to boost mitochondrial ATP production improved T cell migration and antitumor activity, highlighting the pivotal role of mitochondria in CD8+ T cell‐mediated tumor immunity.[69] Despite growing evidence supporting the central role of mitochondrial metabolism in CD8+ T cell function, current studies often examine individual metabolic pathways in isolation, without fully elucidating the spatiotemporal integration of glycolysis, OXPHOS, and lipid metabolism during distinct phases of T cell activation and exhaustion. This evidence concerns the gene CD8A and neoplasm.