NCOA2 and B-cell chronic lymphocytic leukemia: Deficiency in Ncoa2 impairs T‐cell oxidative phosphorylation and IFN‐γ production, diminishing tumor rejection capabilities (Figure 3A).[34] In chronic lymphocytic leukemia (CLL), CD8+ T cells display metabolic reprogramming with diminished GLUT1 reserves and altered mitochondrial dynamics, correlating with impaired activation.