This reprogramming endows T(SCM) cells with heightened recall responses and superior therapeutic efficacy in adoptive cell therapy and immune‐mediated tumor suppression, highlighting mitochondrial metabolism's pivotal role in optimizing T cell function and antitumor activity.[28] Targeting mitochondrial mass, dynamics, redox balance, calcium homeostasis, and metabolism offers a promising strategy to enhance CD8+ T cell‐based immunotherapies, improving T cell function, preventing exhaustion, and optimizing immune responses across various diseases. Here, CD8A is linked to neoplasm.