MMA triggers TOX‐driven transcriptional reprogramming, upregulates exhaustion markers, and suppresses effector activity, thereby weakening anti‐tumor immunity and linking metabolic dysregulation to immune dysfunction in cancer.[55] Additionally, in human CD4+ and CD8+ T cells, glycolysis and mitochondrial activity dynamically change upon activation, impacting proliferation and cytokine production. This evidence concerns the gene CD8A and cancer.