Deletion or silencing of MCJ enhances mitochondrial metabolism, leading to an increase in vitro and in vivo activity of murine and human CD8+ CAR‐T cells against leukemia and melanoma.[108] Similarly, the inclusion of 4‐1BB signaling domains in CAR T cell architecture promotes central memory CD8+ T cells with enhanced mitochondrial biogenesis and FAO, leading to improved respiratory capacity. The gene discussed is CD8A; the disease is melanoma.