PRF1 and cancer: This process is essential for cytokine production, including IL‐2, TNF, IFN‐γ, perforin, and granzyme B. Reprogramming T cells with enforced PGC1α expression restores their metabolic fitness and enhances antitumor activity, highlighting mitochondrial biogenesis as a key target for reinvigorating dysfunctional T cells in cancer therapy.[33] Moreover, Ncoa2 enhances CD8+ T‐cell antitumor responses by upregulating PGC‐1α, thus boosting mitochondrial biogenesis and T‐cell activation.