ETV1 and neoplasm: Following a series of in vitro and in vivo experiments, the authors proposed a paradigm in which ectopic SUMO‐conjugated Etv1 re‐establishes tumor‐initiating capacities in a SUMOylation‐deficient context but leaves tumor cells in a low‐cycling/quiescent state, akin to the CSC phenotype (Fig. 1).