2019). Another study showed that EV‐miR‐92a‐1‐5p from primary PCa downregulates type I collagen expression by directly targeting COL1A1, thereby promoting OC differentiation and inhibiting OB differentiation, thus directly degrading the bone ECM. In this study, EVs produced by osteogenic (MDA‐PCa 2b), osteolytic (PC3) or mixed (C4‐Siegel et al. 2023)) human PCa cells were used; EVs from all three types of PCa stimulated osteoclastogenesis in vitro and provoked osteolysis in vivo (Yu et al. 2021). This evidence concerns the gene COL1A1 and posterior cortical atrophy.