2022). The merits and demerits of interactions between different cell types rely on what they communicate. We found here that IECs secreted iron‐loaded ferritin via the EV pathway to aggravate macrophage inflammatory response. However, semaphorin 7A expression on the basolateral side of IECs induces macrophages to express IL‐10 to ameliorate DSS‐induced colitis (Kang et al. 2012). This evidence concerns the gene IL10 and colitis.