MKI67 and neoplasm: 2022). On the other hand, factors such as cancer stage, tumour size, lymph node involvement, Ki‐67 level, CA15‐3 and CEA levels, and treatment approach did not exhibit significant correlations. Compared to conventional diagnostic methods like CA15‐3, CEA, and mammography, our approach has higher sensitivity (Figure S10). These findings suggested the tdEVprotein score's potential as a predictive tool for patient recurrence, prognosis, and the management of aggressive TNBC.